Question 60 (part 2) · LEK · Treatment

Which of the statements below is true about metformin:

  1. A. it must not be used in obese patients with diabetes type 1.
  2. B. it is the first-line treatment in diabetes types 2, regardless of the patient’s body mass.
  3. C. it should be discontinued when the glomerular filtration rate is 30-45 ml/min/1,73 m2.
  4. D. it might increase the risk of ketoacidosis.
  5. E. its main side effect is constipation.
Hint

Think about the drug's place in type 2 diabetes algorithms and its eGFR thresholds for dose reduction versus withdrawal.

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