Question 254 · LEK · Glomerular diseases
Indicate the true information on Alport’s syndrome of sex-linked inheritance:
1) it is caused by inherited defect in alpha 5 collagen IV chain synthesis and leads to end-stage renal disease;
2) women (heterozygotes) are healthy gene carriers or they have only mild symptoms;
3) haematuria and proteinuria occur in men at around 10 years of age;
4) therapy with cyclosporine inhibits the development of the disease;
5) angiotensin converting enzyme inhibitors are used to decrease proteinuria.
The correct answer is:
2) women (heterozygotes) are healthy gene carriers or they have only mild symptoms;
3) haematuria and proteinuria occur in men at around 10 years of age;
4) therapy with cyclosporine inhibits the development of the disease;
5) angiotensin converting enzyme inhibitors are used to decrease proteinuria.
The correct answer is:
- A. 1,3,5.
- B. 1,3,4.
- C. 1,4,5.
- D. 1,2,5.
- E. 2,4,5.
Hint
Consider which sex is fully affected in an X-linked disease, when hematuria first appears, and which drugs are nephroprotective rather than nephrotoxic.
The answer, the explanation and a note on every option are available once you log in. The account is free: topic tests, a mock exam, mistake review and statistics.
More questions on Internal medicine
- Indicate factors predisposing for contrast nephropathy:
- A 29-year-old female patient has had a fever of 38˚C for the last two weeks despite NSAIDs treatment, complains of a neck pain radiating into the…
- Which blood test should be performed first in a person with tetany attacks?
- Which of the following concerning automatic blood pressure monitoring (ABPM) is false?
- Indicate unfavorable prognostic factors of acute glomerulonephritis:
- The GRACE risk score facilitates decision making in the management of patients with: