Question 117 · LEK · Anticoagulants

A patient on a constant acenocoumarol therapy came to the family doctor with the result of INR=5.8 without any sign of bleeding. Which of the following should be recommended?

  1. A. reduce the weekly dose of acenocoumarol by 10%, without any break in the treatment.
  2. B. withdraw acenocoumarol for 1-2 days till obtaining INR values: 2.0 - 3.0.
  3. C. give immediately ½ tablet of vitamin K and decrease the dose of acenocoumarol for that day.
  4. D. give immediately ½ tablet of vitamin K and withdraw acenocoumarol for 1-2 days.
  5. E. refer the patient to the hospital in order to administer vitamin K intravenously.
Hint

For a moderately raised INR without bleeding, the first step is adjusting the anticoagulant dosing rather than active reversal.

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