Question 57 · LEK · Diagnostic sensitivity and specificity
Researches from the Cleveland Clinic (OH, USA) found that a microbiome present in breast tissue may be associated with breast cancer (Oncotarget 2017; 8:88122-88138). They hope to find a biomarker which help in fast and easy breast cancer diagnosis. Let us assume that they have already found such an biomarker and prepared a diagnostic test for detecting its presence. Using this test they examined 100 women with breast cancer and 100 healthy women who were diagnosed with other methods. They obtained the following results: Indicate the false interpretation of those results:
- A. test sensitivity is 93%.
- B. test specificity is 11%.
- C. the percentage of false positive results is 11%.
- D. the percentage of false negative results is 7%.
- E. the results do not allow to determine a positive and negative predictive value.
Hint
Build the 2x2 table: specificity is calculated within the healthy-women column, and predictive values depend on how cases and controls were sampled.
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