Question 300 · LEK · Leukemias
Although the assessment of cytogenetic and molecular traits is not required in the diagnosis of acute lymphoblastic leukaemia (ALL), they are among the basic classification criteria of ALL. Indicate false statements regarding ALL:
- A. in ALL, B lymphoblasts are almost always positive for B CD19 markers.
- B. in ALL, B lymphoblasts must be negative for CD3 (T cell antigen).
- C. in ALL, B lymphoblasts must be negative for myeloperoxidase (MPO).
- D. B-ALL diagnosis should be avoided when the number of lymphoblasts is <20%.
- E. B-ALL is always diagnosed when the number of lymphoblasts > 5%.
Hint
Recall the minimum percentage of marrow blasts that WHO considers appropriate for diagnosing acute lymphoblastic leukaemia.
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