Question 48 (part 2) · LDEK · Pharmacotherapy in oral surgery
Indicate true statements regarding use of metronidazole in oral surgery:
1) it is a basic drug used in case of actinomycosis, due to the fact that anaerobic bacteria from Actinomyces strain are mostly sensitive to metronidazole;
2) it is characterized by good penetration to bone;
3) in case of mixed anaerobic-aerobic infection, metronidazole should be combined with clindamycin;
4) it is a drug that acts selectively towards bacteria absolutely anaerobic, whereas towards bacteria relatively aerobic, it acts in strictly anaerobic environment;
5) in the treatment of odontogenic infections, it is in combination with amoxicillin.
Correct answer is:
2) it is characterized by good penetration to bone;
3) in case of mixed anaerobic-aerobic infection, metronidazole should be combined with clindamycin;
4) it is a drug that acts selectively towards bacteria absolutely anaerobic, whereas towards bacteria relatively aerobic, it acts in strictly anaerobic environment;
5) in the treatment of odontogenic infections, it is in combination with amoxicillin.
Correct answer is:
- A. 1,2,3.
- B. 3,4,5.
- C. 1,3,4.
- D. 1,2,5.
- E. 2,4,5.
Hint
Recall the first-line antibiotic for actinomycosis and whether clindamycin already covers anaerobes on its own.
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