Question 300 · LDEK · Pharmacotherapy in oral surgery
Choose correct statement regarding non-steroidal inflammatory drugs qualified to the selective inhibitors of COX-2 group:
- A. due to increased risk of cardiovascular complications, drugs belonging to this group need to be cautiously administered in patients with coronary heart diseases.
- B. they constitute a subgroup of NSAIDs with highest drug-induced digestive tract damage risk.
- C. due to their antiaggregant properties, their routine administration in treatment of postoperative pain in oral surgery is not recommended.
- D. drugs belonging to this group should be administered with extreme caution due to their adverse pharmacodynamic profile (thin boundary between the therapeutic and toxic dose).
- E. they should be administered with caution in patients with compromised liver function, due to the possibility of temporary increase of liver enzymes activity.
Hint
Think about what happens to the prostacyclin–thromboxane balance when only COX-2 is blocked.
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