KROK 1 Stomatology 2016 – Question 133 · KROK (Dentistry)
Sulfanilamides are applied as antimicrobial agents in clinical practice. Sulfanilamide treatment, however, can result in hemolytic anemia development in patients that suffer from genetic defect of the following enzyme of pentose phosphate metabolism in erythrocytes:
- A. Pyruvate kinase
- B. Glucose-6-phosphate dehydrogenase
- C. Transaldolase
- D. Transketolase
- E. Hexokinase
Hint
Think which pentose phosphate reaction supplies the NADPH that keeps glutathione reduced and protects red cells from oxidant drugs.
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