KROK 1 Stomatology 2016 – Question 121 · KROK (Dentistry)
A patient with heart failure and tachycardia has been prescribed digoxin. After 5 days of taking digoxin the patient’s heart rate was normalized. After 2 weeks the patient addressed a doctor due to continuous decrease of heart rate down to 52/min. What phenomenon has caused such changes of heart rate?
- A. Idiosyncrasy
- B. Cumulation
- C. Tachyphylaxis
- D. Tolerance
- E. Allergy
Hint
Consider digoxin's long half-life and what happens to its concentration in the body when it is taken daily for weeks.
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