KROK 1 Stomatology 2016 – Question 29 · KROK (Dentistry)
A patient suffers from mutation of a gene that corresponds with hemoglobin synthesis. This condition led to development of sickle-cell disease. Name the pathological hemoglobin characteristic of this disease:
- A. HbA1
- B. HbS
- C. HbA
- D. HbF
- E. Bart-Hb
Hint
Recall the point mutation in the β-globin chain (glutamate replaced by valine) and the abnormal hemoglobin it produces that polymerizes when deoxygenated.
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