KROK 1 Stomatology 2015 – Question 199 · KROK (Dentistry)

Novocaine acts as an anesthetic by making nerve fibers unable to conduct stimulation. What mechanism of action regarding membrane’s permeability to ions does this drug have?

  1. A. Sodium-proton pump blockade
  2. B. Sodium ion-selective channels blockade
  3. C. Potassium ion-selective channels blockade
  4. D. Calcium ion-selective channels blockade
  5. E. Sodium-potassium pump blockade
Hint

Consider which ion current produces the rising phase of the action potential and must be prevented for conduction to stop.

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