KROK 1 Stomatology 2015 – Question 188 · KROK (Dentistry)
Continuous treatment of cancer patients with methotrexate over time reduces the target cell's sensitivity to the drug. In this case gene amplification of the following enzyme is observed:
- A. Deaminase
- B. Dihydrofolate reductase
- C. Thioredoxin reductase
- D. Thiaminase
- E. -
Hint
Identify the enzyme that methotrexate inhibits as a folic acid analogue - overproducing it would overcome the drug.
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