KROK 1 Stomatology 2015 – Question 122 · KROK (Dentistry)
An oncological patient had been administered methotrexate. With time target cells of the tumour lost sensitivity to this drug. At the same time the change in gene expression of the following enzyme is observed:
- A. Folate oxidase
- B. Folate decarboxylase
- C. Deaminase
- D. Thiaminase
- E. Dihydrofolate reductase
Hint
Recall the target enzyme of methotrexate as a folic acid antagonist and how tumour cells can overcome its inhibition by changing gene copy number.
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