KROK 1 Stomatology 2015 – Question 98 · KROK (Dentistry)
A patient, who had been eating only polished rice, developed polyneuritis caused by thiamine deficiency. What compound can be indicative of this kind of avitaminosis when excreted with urine?
- A. Pyruvic acid
- B. Phenylpyruvate
- C. Malate
- D. Uric acid
- E. Methylmalonic acid
Hint
Thiamine pyrophosphate is the coenzyme of oxidative decarboxylation of α-keto acids; think which substrate accumulates when this step fails.
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