KROK 1 Stomatology 2014 – Question 135 · KROK (Dentistry)

In patients with glycogenosis, that is von Gierke’s disease, the conversion of glucose-6-phosphate into glucose is inhibited, which is accompanied by the improper breakdown of glycogen in the liver. The cause of this condition is the following enzyme deficiency:

  1. A. Glycogen phosphorylase
  2. B. Glucose-6-phosphate dehydrogenase
  3. C. Phosphofructokinase
  4. D. Phosphoglucomutase
  5. E. Glucose-6-phosphatase
Hint

Identify the enzyme that catalyses the final step of both glycogenolysis and gluconeogenesis in the liver, releasing free glucose into the blood.

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