KROK 1 Stomatology 2014 – Question 111 · KROK (Dentistry)
A 39-year-old patient with arthritis of the temporomandibular joint has been administered diclofenac sodium. It must be kept in mind that the side effect of prolonged use of this drug is:
- A. Teratogenicity
- B. Ototoxicity
- C. Drug dependence
- D. Ulcerogenicity
- E. Carcinogenicity
Hint
Diclofenac inhibits cyclooxygenase; think about which tissues depend most on COX-1 prostaglandins for their protection during long-term therapy.
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