KROK 1 Stomatology 2014 – Question 2 · KROK (Dentistry)
In some areas of South Africa many people have sickle cell disease characterized by red blood cells that assume an abnormal sickle shape due to the substitution of valine for glutamic acid in the hemoglobin molecule. What is the cause of this disease?
- A. Gene mutation
- B. Transduction
- C. Disturbances of the mechanisms of genetic information transmission
- D. Genomic mutation
- E. Crossing-over
Hint
Consider what kind of change in DNA leads to a single amino acid being replaced in one polypeptide chain.
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