KROK 1 Stomatology 2013 – Question 65 · KROK (Dentistry)
A patient with chronic heart failure has been taking digoxin for several months on an outpatient basis. At a certain stage of treatment, he got symptoms of drug overdose. What effect underlies the development of this complication?
- A. Sensibilization
- B. Tachyphylaxis
- C. Adaptation
- D. Material accumulation
- E. Functional cumulation
Hint
Consider what happens to the plasma concentration of a drug with a long half-life and strong tissue binding when it is taken repeatedly for months.
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