KROK 1 Stomatology 2012 – Question 149 · KROK (Dentistry)
An oncological patient had been administered methotrexate. With time target cells of the tumour lost sensitivity to this drug. At the same time the change in gene expression of the following enzyme is observed:
- A. Deaminase
- B. Folate oxidase
- C. Dihydrofolate reductase
- D. Folate decarboxylase
- E. Thiaminase
Hint
Recall the target enzyme of methotrexate as a folic acid antagonist and how tumour cells can overcome its inhibition by changing gene copy number.
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