KROK 1 Stomatology 2012 – Question 51 · KROK (Dentistry)
A patient suffering from chronic myeloleukemia has got the following symptoms of anemia: decreased number of erythrocytes and low haemoglobin concentration, oxyphilic and polychromatophilic normocytes, microcytes. What is the leading pathogenetic mechanism of anemia development?
- A. Deficiency of vitamin B12
- B. Intravascular hemolysis of erythrocytes
- C. Chronic haemorrhage
- D. Reduced synthesis of erythropoietin
- E. Substitution of haemoblast
Hint
Consider what happens to normal erythroid precursors when the bone marrow is massively filled with leukaemic cells.
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